SCIENCE SIGNALING: Degrading Polyamines for Migration
نویسندگان
چکیده
منابع مشابه
Ubiquitination and auxin signaling: a degrading story.
Signaling pathways are rarely straightforward, and auxin signal transduction is no exception. The diverse events in which auxin is involved tell of the daunting complexity behind the plant’s response to auxin. This one molecule can cause changes in rates of cell division and cell elongation, alter ion fluxes across membranes, cue changes in patterning and differentiation, and affect the express...
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The most commonly occurring of the natural polyamines are putrescine [ Nl ll(CI ll),N14?, a diaminel, spermidine [ Nl 12(C€12)3Nl l(C142),NIIl. a triamine] and spermine [ Nl il(Cl 12);NI l(C€Il),N€I(CI 1?)?NI ?. a tetramine]. One or more of these compounds are present in every living cell. All are found in eukaryotes; spermine is absent from most prokaryotes. The polyamines are essential for ce...
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The interaction between learning at the individual level and the trajectory of a population over time is fundamental to our understanding of linguistic change. Here we use game theory as a mathematical framework for formulating and testing hypotheses about this interaction. We formalize two hypotheses regarding the spread of vowel mergers and use them to derive the proportion of merged in-migra...
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Under a variety of (patho) physiological conditions, leukocytes will leave the bloodstream by crossing the endothelial monolayer that lines the vessels and migrate into the underlying tissues. It is now clear that the process of extravasation involves a range of adhesion molecules on both leukocytes and endothelial cells, as well as extensive intracellular signaling that drives adhesion and che...
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The polyamines (PAs) are ubiquitous polycationic metabolites in eukaryotic and prokaryotic cells and are believed to be intimately involved in the regulation of DNA, RNA, and protein biosynthesis, the exact function of which remains unclear, mainly because of a lack of knowledge of PA subcellular localization. In this study, using immunoelectron microscopy, we have demonstrated that PAs are pre...
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ژورنال
عنوان ژورنال: Science
سال: 2008
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.320.5881.1263c